Zika Virus Cell Structure

Cells infected with dengue virus which is closely related to the zika virus also accumulate sfrna. Nucleocapsid is 25 30 nm in diameter surrounded by a host membrane derived lipid bilayer.

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Inserted into the membrane are 180 copies of the viral proteins e and m.

Zika virus cell structure. It is most closely related to the spondweni virus and is one of the two known viruses in the spondweni virus clade. The cryo em structure of zika virus tells us how the virus particle is put together. A protruding n154 glycosylation site and a more compact surface with higher thermostability.

The genome is a positive strand rna enclosed in a capsid and surrounded by a membrane. They are enveloped 18 45 nanometer in diameter. It looks very much like other flaviviruses which consist of a membrane surrounding the capsid which in turn carries the viral rna genome.

Cryo electron microscopy em structural studies revealed that the zikv particle has two unique features. Structure of zika virus zika virions are typically icosahedral shaped. Zika virus zikv formerly a neglected pathogen has recently been associated with microcephaly in fetuses 1 and with guillian barré syndrome in adults 2.

Once zika virus particles are in the human body they must enter individual cells in order to replicate and make more viruses. Both mature and immature structures of zikv are centered on the 2 fold axis. Cell entry is possible because a zika virus particle carries specific proteins on its outer envelope that interact with receptor proteins on human cells.

A and d are surface shaded radially colored views of mature emd 8116 and immature zikv emd 8508 respectively. Structure of zika virus zikv. Like other flaviviruses zika virus is enveloped and icosahedral and has a nonsegmented single stranded 10 kilobase positive sense rna genome.

The researchers found that the zika virus structure is similar to that of other known flaviviruses except for one region of the envelope glycoprotein. Structure of zika virus the virion is approximately 40 nm in diameter with surface projections that measure roughly 5 10 nm. The genetic material of zika virus is made of ribonucleic acid rna.

Here we present the 3 7 å resolution. A c depict the mature form of zikv 3 8 å resolution whereas d f represent the immature form 9 1 å. When the zika virus infects cells pieces of the virus rna known as subgenomic flavivirus rnas or sfrnas for short accumulate in the cell.

The surface of the flavivirus is composed of a shell made of 180 copies of both an envelope glycoprotein and 1 of 2 other proteins anchored in a lipid membrane.

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