Symptoms are generally mild and include fever rash conjunctivitis muscle and joint pain malaise or headache. Although the first zika infection in humans was reported in a nigerian man in 1953 2 the virus was isolated from humans much later 3.
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Symptoms typically last for 2 7 days.
Zika virus infection cycle. The primary life cycle was mosquito monkey mosquito with an occasional human infection. Briefly the e proteins are involved in the attachment of the virus to receptors on the host membrane. Most people with zika virus infection do not develop symptoms.
Zika virus appears to be contagious via mosquitoes for around a week after infection. The longest time period after symptom onset for which infectious zika virus has been detected by culture in semen is 69 days. Zika virus disease is caused by a virus transmitted primarily by aedes mosquitoes which bite during the day.
Subsequently the virus gets internalised via endocytosis. However zika outbreaks have become widespread and rampant since 2007 when an epidemic occurred in micronesia 4 5. Zika virus life cycle the life cycle of zikv is similar to other known flaviviruses.
The virus is thought to be infectious for a longer period of time after infection at least 2 weeks when transmitted via semen.
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