Rabies virus is excreted in saliva of rabid animal so human acquire virus by the bite of rabid animals. It is the member of the family rhabdoviridae and the genus lyssavirus.
The virus enters the body through transdermal inoculation i e.
Rabies virus pathogenesis. Rabies virus is an enveloped single stranded rna virus with bullet shaped or rod shaped morphology. Saliva cerebrospinal liquid nerve tissue to mucous membranes or skin lesions. Rabies is an infectious viral disease caused by rabies virus.
It affects humans as well as domestic and wild animals. Recent findings indicate that in addition to the rv. Pathogenesis of rabies infection.
The causative agent is rabies virus rv a negative stranded rna virus of the rhabdovirus family. Rabies is a central nervous system cns disease that is almost invariably fatal. In most cases the disease is transmitted via the bite of rabid animals which shed infectious virus with their saliva.
Wounds or direct contact of infectious material i e. The commonest mode of transmission in man is by the bite of a rabid animal or the contamination of scratch wounds by virus infected saliva. However other routes have been implicated in the past such as through mucous membranes of the mouth conjunctiva anus and genitalia.
Virus multiplies in muscle or connective tissue at the site of inoculation and then enter peripheral nerves via motor end plates at neuromuscular junction and spread upto the cns. Rv pathogenesis like that of other viruses is a multigenic trait.
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