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Tuesday, November 3, 2020

Virus With Capsid

There are two major classes of viruses based on the protein capsid. A novel archaeal virus denoted sulfolobus ellipsoid virus 1 sev1 was isolated from an acidic hot spring in costa rica.

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In general there are four main morphological virus types.

Virus with capsid. The capsid and entire virus structure can be mechanically physically probed through atomic force microscopy. A basic structure of virus is nucleic acid core either dna or rna but not both surrounded by protein coat. The morphologically unique virion of sev1 contains a protein capsid with 16 regularly spaced striations and an 11 nm thick envelope.

1 those in which a single or segmented linear nucleic acid molecule with two free ends is essentially completely extended or somewhat coiled a helix and 2 those in which the nucleic acid which may or may not be a covalently closed circle is. Central core of nucleic acid of a virus is called genome and the protein coat surrounding is called as capsid. Certain viruses also have other proteins internal to the capsid.

Forms a shell called a capsid around the nucleic acid. The capsid and inner genome is called the nucleocapsid. Helical these viruses are composed of a single type of capsomere stacked around a central axis to form a helical structure which may have a central cavity or tube.

Capsids are broadly classified according to their structure. It consists of several oligomeric structural subunits made of protein called protomers. The interior interface and exterior features are made up of amino acid residues which afford numerous functionalities for modification via genetic insertion or chemical conjugation.

The capsid structures determined by x ray crystallography show that the dna containing virions and empty capsids have nearly identical structures 11 13. The observable 3 dimensional morphological subunits which may or may not correspond to individual proteins are called capsomeres. A capsid is the protein shell of a virus enclosing its genetic material.

In the case of tomato bushy stunt virus with its t 3 capsid on the other hand the n termini are less ordered and a smaller portion of the rna genome density survives icosahedral averaging. Viral capsids are the protein cage derived from the protein shell of a virus and can have different shapes sizes and protein subunits depending on the virus type 101. Studies of other ssrna virus structures are expected to point to further instances of intermediate behavior for the nature and extent of genome ordering in viral capsids.

The proteins making up the capsid are called capsid proteins or viral coat proteins. The capsid shell comprises 60 copies of 2 viral proteins vp1 and vp2 which are generated by differential mrna splicing with about 90 of the protein in the capsid being vp2 and 10 vp1. Viroids meaning viruslike are disease causing organisms that contain only nucleic acid and have no structural.

In some virus an envelope made up of glycoprotein and phospholipid bilayer is present outside the capsid. Some of these proteins act as enzymes often during the synthesis of viral nucleic acids.

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