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Friday, December 4, 2020

Herpes Virus Lytic Cycle

Biosynthesis stage at this point the virus dna rna takes over the host dna and start producing copies of its own genetic material. Yes herpes uses the lytic cycle.

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Although it travels to the nucleus of the cell it does not insert its genome into the genome of the host cell.

Herpes virus lytic cycle. Here we identify an immediate early gene encoded by kaposi s sarcoma associated herpesvirus kshv human herpesvirus eight hhv8 that activates lytic cycle gene expression from the latent viral genome. Simplex virus hsv 1 and 2 vari cella zoster virus vzv and some avian viruses are referred to alphaherpesvirinae. Herpesviruses exist in two states latency and a lytic productive cycle.

The herpes virus uses the lytic cycle. The alternative cycle is the lysogenic cycle used by bacteriophages. A virus in the lysogenic.

The lytic cycle consist of 5 stages attachment stage the virus attach itself to the host cell in a lock and key way. The alphaherpesvirinae subfamily includes lytic viruses with relatively short life cycle that infect different cell types replicate rapidly and establish latency mainly in sensory ganglia. Penetration stage the virus inject its dna rna into the host cell.

First the virus must be able to evade the immune response of the host and second the virus must be able to halt the lytic cycle. One of the key traits of the herpes virus family is the ability to infect the host with a latent infection and remain in host cells for the life of the host. Among gamma herpesviruses the mechanism of the latency to lytic cycle switch has been studied most intensively in cultured b cells infected with epstein barr virus ebv 7 8.

Although members of this family differ in tissue tropism and many aspects of their interactions with their hosts the mechanisms by which they replicate their dna during productive lytic infection are largely conserved. The herpesviridae are a large family of double stranded dna viruses responsible for many human and veterinary diseases. In this system the viral immediate early gene product variably known as zebra zta or eb1 which contains the ebv bzlf1 orf is capable of driving the entire lytic cycle in b cells and in epithelial cells 9 12.

This cycle is characterized by a virus inserting its viral dna into the genome of the host. This ability is dependent on two factors. Instead it uses enzymes and mechanisms within.

In the lytic cycle the virus lyses or destroys the host cell after the virus has reproduced using the host cell s machinery. In the lysogenic cycle this does not happen.

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