Dengue viruses occur as four antigenically related but distinct serotypes transmitted to humans by aedes aegypti mosquitoes. Ns1 antigen in dengue virus has been shown to regulate complement activation and hence could play a role in the pathogenesis of dhf 12 13 25 27.
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Dengue virus after entering in the body invades the local macrophages and multiply there.
Dengue virus pathogenesis. They may range from subclinical infection to dengue fever dengue hemorrhagic fever dhf and eventually dengue shock syndrome dss. Long term immunity only to the infecting serotype. Clearly immunopathogenic mechanisms are involved in plasma leakage and coagulopathy.
Appears by 14 days after onset of symptoms and persists for life. Dengue igm and igg responses role of ige in pathogenesis total and dengue specific ige antibody levels are higher in dhf and dss patients compare to dd patients total ige levels significantly higher in those previously exposed to dengue infections during severe dengue infection some studies suggest there are suppressed th1 and th2 responses koraka p murgue b deparis x et al. Less frequently isolation of the dengue virus from serum plasma leukocytes or autopsy samples during the early phase of the disease first 4 5 days virus can be detected in serum plasma.
They may range from subclinical infection to dengue fever dengue hemorrhagic fever dhf and eventually dengue shock syndrome dss. Rises for 1 3 weeks and persists for 30 60 days or even up to 90 days. Elevated levels of total and dengue virus specific ige in patients with varying diseases severity.
The dengue virus nonstructural 1 protein ns1 generates antibodies to common epitopes on human blood clotting integrin adhesin proteins and binds to human endothelial cells. These viruses generally cause a benign syndrome dengue fever in the american and african tropics and a severe syndrome dengue hemorrhagic fever dengue shock syndrome dhf dss in southeast asian children. Primary dengue immune response.
Summary much remains to be learned about the pathogenesis of the different manifestations of dengue virus denv infections in humans. Potential implications in haemorrhagic fever pathogenesis. Summary much remains to be learned about the pathogenesis of the different manifestations of dengue virus denv infections in humans.
Produced by 5th day after symptoms appear. As both cell tropism and tissue tropism of denv are considered major determinants in the pathogenesis of dengue there is a. Certain complement fragments such as c3a and c5a are known to enhance permeability.
Infected local cells then migrate from site of infection to lymph nodes where monocytes and macrophages are recruited which become targets of infection.
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