Virus Mutation Rate

Virus mutation rates are described in several ways such as mutations per nucleotide synthesized mutations per genome synthesized or mutations nucleotide cell infection. Rna viruses have high mutation rates up to a million times higher than their hosts and these high rates are correlated with enhanced virulence and evolvability traits considered beneficial for viruses.

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For some rna viruses these numbers translate into one or two mutations per genome replicated.

Virus mutation rate. The resulting rates range from 10 8 to 10 6 s n c for dna viruses and from 10 6 to 10 4 s n c for rna viruses. A group of graduate students in a spring semester bioinformatics and systems biology class at illinois tracked the mutation rate in the virus s proteome the collection of proteins encoded by. The mutation rates of 23 viruses are presented as substitutions per nucleotide per cell infection s n c and corrected for selection bias where necessary using a new statistical method.

However their mutation rates are almost disastrously high and a small increase in mutation rate can cause rna viruses to go locally extinct. Despite high rates of mutation among viruses in general it s unusual to find viruses that change their mode of transmission between humans over such short time scales he wrote.

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